|
KMID : 1161420110140121570
|
|
Journal of Medicinal Food
2011 Volume.14 No. 12 p.1570 ~ p.1575
|
|
|
Evaluation of Soybean Methanol Fraction on Acute Inflammation
|
|
da Silva Carrara Vanessa
Amado Ciomar Bersani
de Melo Juliana Oliveira
Mandarino Jose Marcos Gontijo
Cortez Diogenes Aparicio Garcia
|
|
|
Abstract
|
|
|
|
Soybeans have been of interest of researchers because of the presence of isoflavones, a subclass of flavonoids, which have demonstrated anti-inflammatory activity. The aim of this study was investigate the anti-inflammatory activity of the methanol fraction from soybean, which contains mainly isoflavone glucosides and malonylglucosides. The anti-inflammatory activity of the methanol fraction from soybean was studied using croton oil?induced mouse ear edema and carrageenan-induced pleurisy models. The methanol fraction inhibited the ear edema in a dose-dependent manner: 0.625?mg/kg by 44.23% (P<.05), 1.25?mg/kg by 60.68% (P<.01), and 2.5?mg/kg by 65.68% (P<.01). Myeloperoxidase enzyme activity was reduced at the dose of 2.5?mg/kg (64.79%, P<.05). No effects were seen on carrageenan-induced pleurisy at different doses of the methanol fraction (100 or 400?mg/kg). These results demonstrated that the methanol fraction containing conjugated isoflavones showed topical anti-inflammatory activity. There was no acute toxicity in Swiss mice after oral administration of the fraction, at doses of 1,000, 2,000, 3,000, and 4,000?mg/kg.
|
|
|
KEYWORD
|
|
|
acute toxicity, anti-inflammatory activity, ear edema, isoflavone, soybean
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|
|